Assay Detail
Binding
CHEMBL4418914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST tag LMTK3 kinase domain (133 to 415 amino acids) (unknown origin) expressed in insect cells incubated for 120 mins by radiometric fluorescent detection based CisBio KinEASE STK-S1 kit based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase LMTK3 (CHEMBL4523432) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Methods for categorising cancer such as breast cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.97 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4450227 | — | — | 1 | 9.93 |
| CHEMBL7463 | GF-109203 | — | 1 | 9.88 |
| CHEMBL281948 | K-252A | — | 1 | 7.10 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4450227 | — | IC50 | = | 0.1175 | nM | 9.93 |
| CHEMBL7463 | GF-109203 | IC50 | = | 0.1318 | nM | 9.88 |
| CHEMBL281948 | K-252A | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 0.002399 | nM | - |