Assay Detail
Functional
CHEMBL4419052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at recombinant human N-terminal rat ST3 receptor-fused TAS2R46 expressed in HEK293T cells co-expressing Galpha16gust44 assessed as inhibition of denatonium benzoate-induced increase in intracellular calcium level by FLIPR assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods of identifying antagonists of the hTAS2R46 bitter taste receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.73 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440983 | — | — | 1 | 5.17 |
| CHEMBL4448202 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440983 | — | IC50 | = | 6780.0 | nM | 5.17 |
| CHEMBL4448202 | — | IC50 | = | 51400.0 | nM | 4.29 |