Assay Detail
Binding
CHEMBL4419402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-catenin/BCL9 in Wnt-activated human SW480 cells assessed as reduction in canonical Wnt signaling transactivation by Wnt-responsive luciferase reporter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
beta-catenin-B-cell lymphoma 9 protein complex (CHEMBL3885525) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Substituted n-([1,1''-biphenyl]-3-yl)-[1,1''-biphenyl]-3-carboxamide analogs as inhibitors for beta-catenin/b-cell lymphoma 9 interactions
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.27 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074243 | — | — | 1 | 5.53 |
| CHEMBL484853 | CARNOSIC ACID | — | 1 | 5.28 |
| CHEMBL4460584 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074243 | — | IC50 | = | 2944.0 | nM | 5.53 |
| CHEMBL484853 | CARNOSIC ACID | IC50 | = | 5213.0 | nM | 5.28 |
| CHEMBL4460584 | — | IC50 | = | 9657.0 | nM | 5.01 |