Assay Detail
Binding
CHEMBL4419456
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Inhibition of GFP-tagged human ferroportin expressed in HEK293 #354 cells assessed as reduction in Fpn-mediated iron efflux incubated overnight by iron regulatory element -driven beta-lactamase reporter gene assay
130
Total Activities
130
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Ferroportin Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 130 | 5.45 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564862 | — | — | 1 | 7.01 |
| CHEMBL4456285 | — | — | 1 | 7.00 |
| CHEMBL4528718 | — | — | 1 | 6.77 |
| CHEMBL4575243 | — | — | 1 | 6.77 |
| CHEMBL4475199 | VAMIFEPORT HYDROCHLORIDE | 1.0 | 1 | 6.38 |
| CHEMBL4442485 | — | — | 1 | 6.34 |
| CHEMBL4476775 | — | — | 1 | 6.33 |
| CHEMBL4565338 | — | — | 1 | 6.30 |
| CHEMBL4539480 | — | — | 1 | 6.28 |
| CHEMBL4573733 | — | — | 1 | 6.21 |
| CHEMBL4585912 | — | — | 1 | 6.21 |
| CHEMBL4445738 | — | — | 1 | 6.20 |
| CHEMBL4456611 | — | — | 1 | 6.20 |
| CHEMBL4553819 | — | — | 1 | 6.14 |
| CHEMBL4585288 | — | — | 1 | 6.13 |
| CHEMBL4470632 | — | — | 1 | 6.13 |
| CHEMBL4592063 | — | — | 1 | 6.12 |
| CHEMBL4521298 | — | — | 1 | 6.12 |
| CHEMBL4466318 | — | — | 1 | 6.08 |
| CHEMBL4520569 | — | — | 1 | 6.06 |
| CHEMBL4587045 | — | — | 1 | 6.03 |
| CHEMBL4462224 | — | — | 1 | 5.99 |
| CHEMBL4518192 | — | — | 1 | 5.96 |
| CHEMBL4588189 | — | — | 1 | 5.95 |
| CHEMBL4441062 | — | — | 1 | 5.94 |
| CHEMBL4442719 | — | — | 1 | 5.91 |
| CHEMBL4573402 | — | — | 1 | 5.91 |
| CHEMBL4516922 | — | — | 1 | 5.90 |
| CHEMBL4453626 | — | — | 1 | 5.90 |
| CHEMBL4573779 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564862 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4456285 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4575243 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4528718 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4475199 | VAMIFEPORT HYDROCHLORIDE | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4442485 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4476775 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4565338 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4539480 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4585912 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4573733 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4445738 | — | EC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4456611 | — | EC50 | = | 628.0 | nM | 6.20 |
| CHEMBL4553819 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4585288 | — | EC50 | = | 734.0 | nM | 6.13 |
| CHEMBL4470632 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4521298 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4592063 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4466318 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4520569 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4587045 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4462224 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4518192 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4588189 | — | EC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL4441062 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4442719 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4573402 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4453626 | — | EC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL4516922 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4573779 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4589376 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4593358 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4579471 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4536578 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4443017 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4447099 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4464039 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4470704 | — | EC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4464486 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4530497 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4442044 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4437679 | — | EC50 | = | 1998.0 | nM | 5.70 |
| CHEMBL4593321 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4453697 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4468502 | — | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4543450 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4581730 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4569416 | — | EC50 | = | 2525.0 | nM | 5.60 |
| CHEMBL4440019 | — | EC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4449134 | — | EC50 | = | 2620.0 | nM | 5.58 |