Assay Detail
Binding
CHEMBL4420245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RPE65 in rat RPE microsomes assessed as reduction in isomero-hydrolase activity by measuring 11-cis-retinol generation using all-trans-[3H]-retinol by HPLC analysis
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compositions and methods of inhibiting retinal degeneration
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13210 | — | — | 2 | 4.00 |
| CHEMBL4475224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13210 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL13210 | — | Inhibition | - | % | - | |
| CHEMBL4475224 | — | Inhibition | - | % | - |