Assay Detail
Functional
CHEMBL4420666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of cell proliferation of C57BL/6 mouse hepatic progenitor cells assessed as conversion of hepatic progenitor cells into small organoids by measuring mean number of nuclei per organoid incubated for 4 days Hoechst-33342 staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.33 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572019 | — | — | 1 | 6.58 |
| CHEMBL4571192 | — | — | 1 | 6.08 |
| CHEMBL4463799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572019 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4571192 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4463799 | — | EC50 | > | 20000.0 | nM | - |