Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4420671

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LATS in human JHH5 cells assessed as reduction in YAP phosphorylation level incubated for 2 hrs by HTRF assay
ChEMBL ↗
284
Total Activities
284
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Serine/threonine-protein kinase LATS (CHEMBL4523992) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 284 5.62 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4571192 — — 1 6.22
CHEMBL4577857 — — 1 6.22
CHEMBL4454440 — — 1 6.22
CHEMBL4572019 — — 1 6.22
CHEMBL4444109 — — 1 6.10
CHEMBL4438081 — — 1 6.10
CHEMBL4573735 — — 1 6.10
CHEMBL4446217 — — 1 6.05
CHEMBL4472973 — — 1 6.00
CHEMBL4555291 — — 1 6.00
CHEMBL4590309 — — 1 6.00
CHEMBL4439972 — — 1 6.00
CHEMBL4551441 — — 1 5.96
CHEMBL4464441 — — 1 5.96
CHEMBL4450439 — — 1 5.89
CHEMBL4483764 — — 1 5.89
CHEMBL4458233 — — 1 5.89
CHEMBL4563697 — — 1 5.89
CHEMBL4518582 — — 1 5.85
CHEMBL4564805 — — 1 5.82
CHEMBL4447080 — — 1 5.82
CHEMBL4444003 — — 1 5.82
CHEMBL4471995 — — 1 5.80
CHEMBL4533967 — — 1 5.80
CHEMBL4585067 — — 1 5.77
CHEMBL4513243 — — 1 5.77
CHEMBL4470612 — — 1 5.72
CHEMBL4525078 — — 1 5.70
CHEMBL4517252 — — 1 5.68
CHEMBL4446641 — — 1 5.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4571192 — IC50 = 600.0 nM 6.22
CHEMBL4577857 — IC50 = 600.0 nM 6.22
CHEMBL4572019 — IC50 = 600.0 nM 6.22
CHEMBL4454440 — IC50 = 600.0 nM 6.22
CHEMBL4444109 — IC50 = 800.0 nM 6.10
CHEMBL4438081 — IC50 = 800.0 nM 6.10
CHEMBL4573735 — IC50 = 800.0 nM 6.10
CHEMBL4446217 — IC50 = 900.0 nM 6.05
CHEMBL4472973 — IC50 = 1000.0 nM 6.00
CHEMBL4439972 — IC50 = 1000.0 nM 6.00
CHEMBL4555291 — IC50 = 1000.0 nM 6.00
CHEMBL4590309 — IC50 = 1000.0 nM 6.00
CHEMBL4551441 — IC50 = 1100.0 nM 5.96
CHEMBL4464441 — IC50 = 1100.0 nM 5.96
CHEMBL4458233 — IC50 = 1300.0 nM 5.89
CHEMBL4483764 — IC50 = 1300.0 nM 5.89
CHEMBL4563697 — IC50 = 1300.0 nM 5.89
CHEMBL4450439 — IC50 = 1300.0 nM 5.89
CHEMBL4518582 — IC50 = 1400.0 nM 5.85
CHEMBL4564805 — IC50 = 1500.0 nM 5.82
CHEMBL4447080 — IC50 = 1500.0 nM 5.82
CHEMBL4444003 — IC50 = 1500.0 nM 5.82
CHEMBL4471995 — IC50 = 1600.0 nM 5.80
CHEMBL4533967 — IC50 = 1600.0 nM 5.80
CHEMBL4513243 — IC50 = 1700.0 nM 5.77
CHEMBL4585067 — IC50 = 1700.0 nM 5.77
CHEMBL4470612 — IC50 = 1900.0 nM 5.72
CHEMBL4525078 — IC50 = 2000.0 nM 5.70
CHEMBL4517252 — IC50 = 2100.0 nM 5.68
CHEMBL4446641 — IC50 = 2100.0 nM 5.68
CHEMBL4520049 — IC50 = 2200.0 nM 5.66
CHEMBL4470043 — IC50 = 2200.0 nM 5.66
CHEMBL4558207 — IC50 = 2300.0 nM 5.64
CHEMBL4576185 — IC50 = 2400.0 nM 5.62
CHEMBL4464251 — IC50 = 2600.0 nM 5.58
CHEMBL4450447 — IC50 = 2600.0 nM 5.58
CHEMBL4574721 — IC50 = 2900.0 nM 5.54
CHEMBL4522021 — IC50 = 3000.0 nM 5.52
CHEMBL4456826 — IC50 = 3100.0 nM 5.51
CHEMBL4547932 — IC50 = 3200.0 nM 5.50
CHEMBL4447153 — IC50 = 3200.0 nM 5.50
CHEMBL4440182 — IC50 = 3200.0 nM 5.50
CHEMBL4529548 — IC50 = 3300.0 nM 5.48
CHEMBL4592930 — IC50 = 3400.0 nM 5.47
CHEMBL4437570 — IC50 = 3500.0 nM 5.46
CHEMBL4520021 — IC50 = 3800.0 nM 5.42
CHEMBL4463150 — IC50 = 4000.0 nM 5.40
CHEMBL4470520 — IC50 = 4000.0 nM 5.40
CHEMBL4465888 — IC50 = 4100.0 nM 5.39
CHEMBL4578137 — IC50 = 4600.0 nM 5.34