Assay Detail
Binding
CHEMBL4420917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Dusp6 in (Tg(Dusp6:d2EGFP)pt6) transgenic Zebrafish assessed as activation of FGF signaling treated at 24 hours post fertilization and measured after 6 hrs post dose by d2EGFP fluorescence based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Danio rerio |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase (CHEMBL4523361) ↗| Type | SINGLE PROTEIN |
| Organism | Danio rerio |
Publication
Small molecule inhibitors of Dusp6 and uses therefor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.98 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436546 | — | — | 1 | 5.31 |
| CHEMBL4440035 | — | — | 1 | 4.96 |
| CHEMBL1241589 | — | — | 1 | 4.94 |
| CHEMBL4534585 | — | — | 1 | 4.92 |
| CHEMBL4576068 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436546 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4440035 | — | EC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1241589 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4534585 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4576068 | — | EC50 | = | 18000.0 | nM | 4.75 |