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Assay Detail

CHEMBL4421023

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human amylin receptor expressed in BHK570 cells co-expressing RAMP3 assessed as increase in intracellular cAMP concentration incubated for 3 hrs in absence of albumin by CRE luciferase reporter gene assay
ChEMBL ↗
143
Total Activities
143
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2111190) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 143 10.47 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4447986 — — 1 11.00
CHEMBL4566888 — — 1 11.00
CHEMBL4592228 — — 1 11.00
CHEMBL4560310 — — 1 11.00
CHEMBL4559158 — — 1 11.00
CHEMBL4539553 — — 1 11.00
CHEMBL4579644 — — 1 11.00
CHEMBL4548390 — — 1 11.00
CHEMBL4448157 — — 1 11.00
CHEMBL4459108 — — 1 10.96
CHEMBL4451589 — — 1 10.96
CHEMBL4516363 — — 1 10.96
CHEMBL4565938 — — 1 10.96
CHEMBL4463899 — — 1 10.92
CHEMBL4473161 — — 1 10.92
CHEMBL4453062 — — 1 10.92
CHEMBL4532967 — — 1 10.92
CHEMBL4548044 — — 1 10.89
CHEMBL4460698 — — 1 10.89
CHEMBL4440938 — — 1 10.85
CHEMBL4441747 — — 1 10.85
CHEMBL4574480 — — 1 10.85
CHEMBL4443991 — — 1 10.82
CHEMBL4475352 — — 1 10.82
CHEMBL4471564 — — 1 10.80
CHEMBL4545478 — — 1 10.80
CHEMBL4443487 — — 1 10.80
CHEMBL4474371 — — 1 10.80
CHEMBL4446788 — — 1 10.77
CHEMBL4463230 — — 1 10.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4539553 — EC50 = 0.01 nM 11.00
CHEMBL4579644 — EC50 = 0.01 nM 11.00
CHEMBL4566888 — EC50 = 0.01 nM 11.00
CHEMBL4447986 — EC50 = 0.01 nM 11.00
CHEMBL4592228 — EC50 = 0.01 nM 11.00
CHEMBL4559158 — EC50 = 0.01 nM 11.00
CHEMBL4448157 — EC50 = 0.01 nM 11.00
CHEMBL4560310 — EC50 = 0.01 nM 11.00
CHEMBL4548390 — EC50 = 0.01 nM 11.00
CHEMBL4565938 — EC50 = 0.011 nM 10.96
CHEMBL4516363 — EC50 = 0.011 nM 10.96
CHEMBL4459108 — EC50 = 0.011 nM 10.96
CHEMBL4451589 — EC50 = 0.011 nM 10.96
CHEMBL4473161 — EC50 = 0.012 nM 10.92
CHEMBL4453062 — EC50 = 0.012 nM 10.92
CHEMBL4463899 — EC50 = 0.012 nM 10.92
CHEMBL4532967 — EC50 = 0.012 nM 10.92
CHEMBL4460698 — EC50 = 0.013 nM 10.89
CHEMBL4548044 — EC50 = 0.013 nM 10.89
CHEMBL4574480 — EC50 = 0.014 nM 10.85
CHEMBL4440938 — EC50 = 0.014 nM 10.85
CHEMBL4441747 — EC50 = 0.014 nM 10.85
CHEMBL4475352 — EC50 = 0.015 nM 10.82
CHEMBL4443991 — EC50 = 0.015 nM 10.82
CHEMBL4474371 — EC50 = 0.016 nM 10.80
CHEMBL4471564 — EC50 = 0.016 nM 10.80
CHEMBL4443487 — EC50 = 0.016 nM 10.80
CHEMBL4545478 — EC50 = 0.016 nM 10.80
CHEMBL4452748 — EC50 = 0.017 nM 10.77
CHEMBL4573370 — EC50 = 0.017 nM 10.77
CHEMBL4446788 — EC50 = 0.017 nM 10.77
CHEMBL4463230 — EC50 = 0.017 nM 10.77
CHEMBL4575327 — EC50 = 0.018 nM 10.74
CHEMBL4580170 — EC50 = 0.018 nM 10.74
CHEMBL4519563 — EC50 = 0.018 nM 10.74
CHEMBL4557924 — EC50 = 0.018 nM 10.74
CHEMBL4572498 — EC50 = 0.02 nM 10.70
CHEMBL4540155 — EC50 = 0.02 nM 10.70
CHEMBL4457292 — EC50 = 0.02 nM 10.70
CHEMBL4471035 — EC50 = 0.02 nM 10.70
CHEMBL4544971 — EC50 = 0.02 nM 10.70
CHEMBL4572775 — EC50 = 0.021 nM 10.68
CHEMBL4439140 — EC50 = 0.022 nM 10.66
CHEMBL4443697 — EC50 = 0.022 nM 10.66
CHEMBL4535221 — EC50 = 0.022 nM 10.66
CHEMBL4538888 — EC50 = 0.022 nM 10.66
CHEMBL4568742 — EC50 = 0.023 nM 10.64
CHEMBL4552249 — EC50 = 0.023 nM 10.64
CHEMBL4450060 — EC50 = 0.023 nM 10.64
CHEMBL4451821 — EC50 = 0.024 nM 10.62