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Assay Detail

CHEMBL4421026

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Functional
Agonist activity at human calcitonin receptor expressed in BHK570 cells assessed as increase in intracellular cAMP concentration incubated for 3 hrs in presence of 10% FBS by CRE luciferase reporter gene assay
ChEMBL ↗
96
Total Activities
96
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calcitonin receptor (CHEMBL1832) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 96 10.28 10.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4443487 — — 1 10.96
CHEMBL4539553 — — 1 10.96
CHEMBL4516363 — — 1 10.96
CHEMBL4439362 — — 1 10.89
CHEMBL4559158 — — 1 10.82
CHEMBL4548044 — — 1 10.72
CHEMBL4538977 — — 1 10.72
CHEMBL4476083 — — 1 10.66
CHEMBL4436860 — — 1 10.66
CHEMBL4454002 — — 1 10.66
CHEMBL4540155 — — 1 10.64
CHEMBL4443697 — — 1 10.62
CHEMBL4519563 — — 1 10.60
CHEMBL4451821 — — 1 10.60
CHEMBL4451589 — — 1 10.59
CHEMBL4475352 — — 1 10.57
CHEMBL4473161 — — 1 10.55
CHEMBL4453619 — — 1 10.55
CHEMBL4460698 — — 1 10.54
CHEMBL4570633 — — 1 10.52
CHEMBL4466125 — — 1 10.52
CHEMBL4475282 — — 1 10.52
CHEMBL4440442 — — 1 10.51
CHEMBL4469128 — — 1 10.47
CHEMBL4446788 — — 1 10.46
CHEMBL4521465 — — 1 10.46
CHEMBL4453717 — — 1 10.44
CHEMBL4584790 — — 1 10.43
CHEMBL4438518 — — 1 10.43
CHEMBL4476858 — — 1 10.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4443487 — EC50 = 0.011 nM 10.96
CHEMBL4516363 — EC50 = 0.011 nM 10.96
CHEMBL4539553 — EC50 = 0.011 nM 10.96
CHEMBL4439362 — EC50 = 0.013 nM 10.89
CHEMBL4559158 — EC50 = 0.015 nM 10.82
CHEMBL4548044 — EC50 = 0.019 nM 10.72
CHEMBL4538977 — EC50 = 0.019 nM 10.72
CHEMBL4476083 — EC50 = 0.022 nM 10.66
CHEMBL4436860 — EC50 = 0.022 nM 10.66
CHEMBL4454002 — EC50 = 0.022 nM 10.66
CHEMBL4540155 — EC50 = 0.023 nM 10.64
CHEMBL4443697 — EC50 = 0.024 nM 10.62
CHEMBL4451821 — EC50 = 0.025 nM 10.60
CHEMBL4519563 — EC50 = 0.025 nM 10.60
CHEMBL4451589 — EC50 = 0.026 nM 10.59
CHEMBL4475352 — EC50 = 0.027 nM 10.57
CHEMBL4473161 — EC50 = 0.028 nM 10.55
CHEMBL4453619 — EC50 = 0.028 nM 10.55
CHEMBL4460698 — EC50 = 0.029 nM 10.54
CHEMBL4570633 — EC50 = 0.03 nM 10.52
CHEMBL4466125 — EC50 = 0.03 nM 10.52
CHEMBL4475282 — EC50 = 0.03 nM 10.52
CHEMBL4440442 — EC50 = 0.031 nM 10.51
CHEMBL4469128 — EC50 = 0.034 nM 10.47
CHEMBL4521465 — EC50 = 0.035 nM 10.46
CHEMBL4446788 — EC50 = 0.035 nM 10.46
CHEMBL4453717 — EC50 = 0.036 nM 10.44
CHEMBL4584790 — EC50 = 0.037 nM 10.43
CHEMBL4438518 — EC50 = 0.037 nM 10.43
CHEMBL4476858 — EC50 = 0.037 nM 10.43
CHEMBL4580205 — EC50 = 0.038 nM 10.42
CHEMBL4544971 — EC50 = 0.04 nM 10.40
CHEMBL4443150 — EC50 = 0.04 nM 10.40
CHEMBL4451330 — EC50 = 0.042 nM 10.38
CHEMBL4463679 — EC50 = 0.042 nM 10.38
CHEMBL4572775 — EC50 = 0.044 nM 10.36
CHEMBL4452007 — EC50 = 0.045 nM 10.35
CHEMBL4463230 — EC50 = 0.048 nM 10.32
CHEMBL4439140 — EC50 = 0.048 nM 10.32
CHEMBL4472810 — EC50 = 0.048 nM 10.32
CHEMBL4535221 — EC50 = 0.049 nM 10.31
CHEMBL4557587 — EC50 = 0.049 nM 10.31
CHEMBL4548390 — EC50 = 0.05 nM 10.30
CHEMBL4557533 — EC50 = 0.05 nM 10.30
CHEMBL4474371 — EC50 = 0.05 nM 10.30
CHEMBL4471035 — EC50 = 0.051 nM 10.29
CHEMBL4515255 — EC50 = 0.053 nM 10.28
CHEMBL4585550 — EC50 = 0.053 nM 10.28
CHEMBL4470097 — EC50 = 0.053 nM 10.28
CHEMBL4459158 — EC50 = 0.054 nM 10.27