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Assay Detail

CHEMBL4421072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled rat amylin from human amylin receptor expressed in BHK tkts13 whole cells co-expressing RAMP3 incubated for 60 mins by scintillation proximity assay
ChEMBL ↗
91
Total Activities
91
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2111190) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 91 8.87 10.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4575271 — — 1 10.10
CHEMBL4452007 — — 1 9.96
CHEMBL4568742 — — 1 9.94
CHEMBL4567286 — — 1 9.85
CHEMBL4472810 — — 1 9.73
CHEMBL4538977 — — 1 9.73
CHEMBL4535221 — — 1 9.65
CHEMBL4451589 — — 1 9.62
CHEMBL4476858 — — 1 9.61
CHEMBL4469301 — — 1 9.56
CHEMBL4442024 — — 1 9.56
CHEMBL4440938 — — 1 9.49
CHEMBL4537571 — — 1 9.48
CHEMBL4539249 — — 1 9.47
CHEMBL4566888 — — 1 9.45
CHEMBL4445545 — — 1 9.43
CHEMBL4474699 — — 1 9.43
CHEMBL4441747 — — 1 9.42
CHEMBL4447986 — — 1 9.40
CHEMBL4471564 — — 1 9.38
CHEMBL4474181 — — 1 9.37
CHEMBL4519352 — — 1 9.37
CHEMBL4519563 — — 1 9.37
CHEMBL4517310 — — 1 9.37
CHEMBL4448157 — — 1 9.36
CHEMBL4548534 — — 1 9.33
CHEMBL4442541 — — 1 9.30
CHEMBL4583330 — — 1 9.29
CHEMBL4441429 — — 1 9.29
CHEMBL4460111 — — 1 9.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4575271 — IC50 = 0.079 nM 10.10
CHEMBL4452007 — IC50 = 0.111 nM 9.96
CHEMBL4568742 — IC50 = 0.116 nM 9.94
CHEMBL4567286 — IC50 = 0.142 nM 9.85
CHEMBL4472810 — IC50 = 0.186 nM 9.73
CHEMBL4538977 — IC50 = 0.187 nM 9.73
CHEMBL4535221 — IC50 = 0.222 nM 9.65
CHEMBL4451589 — IC50 = 0.24 nM 9.62
CHEMBL4476858 — IC50 = 0.244 nM 9.61
CHEMBL4469301 — IC50 = 0.278 nM 9.56
CHEMBL4442024 — IC50 = 0.275 nM 9.56
CHEMBL4440938 — IC50 = 0.323 nM 9.49
CHEMBL4537571 — IC50 = 0.329 nM 9.48
CHEMBL4539249 — IC50 = 0.338 nM 9.47
CHEMBL4566888 — IC50 = 0.352 nM 9.45
CHEMBL4445545 — IC50 = 0.375 nM 9.43
CHEMBL4474699 — IC50 = 0.374 nM 9.43
CHEMBL4441747 — IC50 = 0.383 nM 9.42
CHEMBL4447986 — IC50 = 0.4 nM 9.40
CHEMBL4471564 — IC50 = 0.417 nM 9.38
CHEMBL4474181 — IC50 = 0.428 nM 9.37
CHEMBL4519352 — IC50 = 0.431 nM 9.37
CHEMBL4519563 — IC50 = 0.432 nM 9.37
CHEMBL4517310 — IC50 = 0.429 nM 9.37
CHEMBL4448157 — IC50 = 0.435 nM 9.36
CHEMBL4548534 — IC50 = 0.469 nM 9.33
CHEMBL4442541 — IC50 = 0.498 nM 9.30
CHEMBL4583330 — IC50 = 0.511 nM 9.29
CHEMBL4441429 — IC50 = 0.511 nM 9.29
CHEMBL4460111 — IC50 = 0.587 nM 9.23
CHEMBL4576946 — IC50 = 0.588 nM 9.23
CHEMBL4476083 — IC50 = 0.608 nM 9.22
CHEMBL4462943 — IC50 = 0.606 nM 9.22
CHEMBL4540998 — IC50 = 0.653 nM 9.19
CHEMBL4514388 — IC50 = 0.652 nM 9.19
CHEMBL4463230 — IC50 = 0.697 nM 9.16
CHEMBL4462020 — IC50 = 0.745 nM 9.13
CHEMBL4539553 — IC50 = 0.764 nM 9.12
CHEMBL4580205 — IC50 = 0.801 nM 9.10
CHEMBL4532967 — IC50 = 0.796 nM 9.10
CHEMBL4570144 — IC50 = 0.812 nM 9.09
CHEMBL4572498 — IC50 = 0.824 nM 9.08
CHEMBL4443871 — IC50 = 0.83 nM 9.08
CHEMBL4534979 — IC50 = 0.832 nM 9.08
CHEMBL4459315 — IC50 = 0.891 nM 9.05
CHEMBL4446524 — IC50 = 0.902 nM 9.04
CHEMBL4451824 — IC50 = 0.982 nM 9.01
CHEMBL4579644 — IC50 = 0.998 nM 9.00
CHEMBL4514098 — IC50 = 1.067 nM 8.97
CHEMBL4438646 — IC50 = 1.144 nM 8.94