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Assay Detail

CHEMBL4421073

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled human calcitonin from human calcitonin receptor expressed in BHK tkts13 whole cells incubated for 60 mins by scintillation proximity assay
ChEMBL ↗
91
Total Activities
91
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calcitonin receptor (CHEMBL1832) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 91 8.90 9.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4451589 — — 1 9.73
CHEMBL4568742 — — 1 9.70
CHEMBL4474699 — — 1 9.66
CHEMBL4537571 — — 1 9.55
CHEMBL4580205 — — 1 9.52
CHEMBL4566888 — — 1 9.51
CHEMBL4472810 — — 1 9.51
CHEMBL4575271 — — 1 9.51
CHEMBL4538977 — — 1 9.50
CHEMBL4476858 — — 1 9.50
CHEMBL4469301 — — 1 9.49
CHEMBL4445545 — — 1 9.46
CHEMBL4519563 — — 1 9.45
CHEMBL4517310 — — 1 9.43
CHEMBL4452007 — — 1 9.41
CHEMBL4583330 — — 1 9.38
CHEMBL4442541 — — 1 9.38
CHEMBL4447986 — — 1 9.38
CHEMBL4441429 — — 1 9.37
CHEMBL4463230 — — 1 9.36
CHEMBL4476083 — — 1 9.36
CHEMBL4567286 — — 1 9.35
CHEMBL4442024 — — 1 9.32
CHEMBL4440938 — — 1 9.32
CHEMBL4548534 — — 1 9.32
CHEMBL4441747 — — 1 9.30
CHEMBL4438646 — — 1 9.29
CHEMBL4471564 — — 1 9.28
CHEMBL4451824 — — 1 9.28
CHEMBL4443871 — — 1 9.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4451589 — IC50 = 0.188 nM 9.73
CHEMBL4568742 — IC50 = 0.2 nM 9.70
CHEMBL4474699 — IC50 = 0.219 nM 9.66
CHEMBL4537571 — IC50 = 0.279 nM 9.55
CHEMBL4580205 — IC50 = 0.3 nM 9.52
CHEMBL4566888 — IC50 = 0.309 nM 9.51
CHEMBL4472810 — IC50 = 0.307 nM 9.51
CHEMBL4575271 — IC50 = 0.312 nM 9.51
CHEMBL4538977 — IC50 = 0.315 nM 9.50
CHEMBL4476858 — IC50 = 0.318 nM 9.50
CHEMBL4469301 — IC50 = 0.326 nM 9.49
CHEMBL4445545 — IC50 = 0.351 nM 9.46
CHEMBL4519563 — IC50 = 0.352 nM 9.45
CHEMBL4517310 — IC50 = 0.368 nM 9.43
CHEMBL4452007 — IC50 = 0.385 nM 9.41
CHEMBL4583330 — IC50 = 0.419 nM 9.38
CHEMBL4447986 — IC50 = 0.413 nM 9.38
CHEMBL4442541 — IC50 = 0.413 nM 9.38
CHEMBL4441429 — IC50 = 0.431 nM 9.37
CHEMBL4463230 — IC50 = 0.438 nM 9.36
CHEMBL4476083 — IC50 = 0.442 nM 9.36
CHEMBL4567286 — IC50 = 0.45 nM 9.35
CHEMBL4442024 — IC50 = 0.473 nM 9.32
CHEMBL4440938 — IC50 = 0.478 nM 9.32
CHEMBL4548534 — IC50 = 0.481 nM 9.32
CHEMBL4441747 — IC50 = 0.506 nM 9.30
CHEMBL4438646 — IC50 = 0.515 nM 9.29
CHEMBL4471564 — IC50 = 0.523 nM 9.28
CHEMBL4451824 — IC50 = 0.52 nM 9.28
CHEMBL4443871 — IC50 = 0.541 nM 9.27
CHEMBL4519352 — IC50 = 0.547 nM 9.26
CHEMBL4459315 — IC50 = 0.57 nM 9.24
CHEMBL4534979 — IC50 = 0.577 nM 9.24
CHEMBL4474181 — IC50 = 0.59 nM 9.23
CHEMBL4460111 — IC50 = 0.605 nM 9.22
CHEMBL4576946 — IC50 = 0.628 nM 9.20
CHEMBL4514388 — IC50 = 0.651 nM 9.19
CHEMBL4572498 — IC50 = 0.749 nM 9.13
CHEMBL4532967 — IC50 = 0.736 nM 9.13
CHEMBL4535221 — IC50 = 0.747 nM 9.13
CHEMBL4516363 — IC50 = 0.767 nM 9.12
CHEMBL4462020 — IC50 = 0.752 nM 9.12
CHEMBL4539249 — IC50 = 0.796 nM 9.10
CHEMBL4446524 — IC50 = 0.798 nM 9.10
CHEMBL4540998 — IC50 = 0.821 nM 9.09
CHEMBL4448157 — IC50 = 0.834 nM 9.08
CHEMBL4539553 — IC50 = 0.855 nM 9.07
CHEMBL4570144 — IC50 = 0.943 nM 9.03
CHEMBL4565938 — IC50 = 0.959 nM 9.02
CHEMBL4443991 — IC50 = 0.981 nM 9.01