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Assay Detail

CHEMBL4421178

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of pig skin LOX incubated for 45 mins by Amplex red dye based and HRP coupled assay
ChEMBL ↗
91
Total Activities
91
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 91 5.78 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4443447 — — 1 6.52
CHEMBL4458145 — — 1 6.47
CHEMBL4562392 — — 1 6.40
CHEMBL4536193 — — 1 6.38
CHEMBL4458662 — — 1 6.36
CHEMBL4551019 — — 1 6.35
CHEMBL4520208 — — 1 6.35
CHEMBL4548374 — — 1 6.33
CHEMBL4535726 — — 1 6.32
CHEMBL4453938 — — 1 6.29
CHEMBL4434666 — — 1 6.28
CHEMBL4435099 — — 1 6.26
CHEMBL4472470 — — 1 6.23
CHEMBL4526964 — — 1 6.21
CHEMBL4573522 — — 1 6.16
CHEMBL4585775 — — 1 6.14
CHEMBL4438675 — — 1 6.13
CHEMBL4578630 — — 1 6.12
CHEMBL4434955 — — 1 6.11
CHEMBL4536971 — — 1 6.11
CHEMBL4553578 — — 1 6.09
CHEMBL4474125 — — 1 6.08
CHEMBL4441173 — — 1 6.05
CHEMBL4578527 — — 1 6.04
CHEMBL4434669 — — 1 6.04
CHEMBL4459355 — — 1 6.03
CHEMBL4571822 — — 1 6.00
CHEMBL4443558 — — 1 6.00
CHEMBL4541757 — — 1 5.96
CHEMBL4564517 — — 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4443447 — IC50 = 300.0 nM 6.52
CHEMBL4458145 — IC50 = 340.0 nM 6.47
CHEMBL4562392 — IC50 = 400.0 nM 6.40
CHEMBL4536193 — IC50 = 420.0 nM 6.38
CHEMBL4458662 — IC50 = 440.0 nM 6.36
CHEMBL4551019 — IC50 = 450.0 nM 6.35
CHEMBL4520208 — IC50 = 450.0 nM 6.35
CHEMBL4548374 — IC50 = 470.0 nM 6.33
CHEMBL4535726 — IC50 = 480.0 nM 6.32
CHEMBL4453938 — IC50 = 510.0 nM 6.29
CHEMBL4434666 — IC50 = 530.0 nM 6.28
CHEMBL4435099 — IC50 = 550.0 nM 6.26
CHEMBL4472470 — IC50 = 590.0 nM 6.23
CHEMBL4526964 — IC50 = 620.0 nM 6.21
CHEMBL4573522 — IC50 = 690.0 nM 6.16
CHEMBL4585775 — IC50 = 720.0 nM 6.14
CHEMBL4438675 — IC50 = 740.0 nM 6.13
CHEMBL4578630 — IC50 = 760.0 nM 6.12
CHEMBL4434955 — IC50 = 770.0 nM 6.11
CHEMBL4536971 — IC50 = 770.0 nM 6.11
CHEMBL4553578 — IC50 = 820.0 nM 6.09
CHEMBL4474125 — IC50 = 830.0 nM 6.08
CHEMBL4441173 — IC50 = 890.0 nM 6.05
CHEMBL4578527 — IC50 = 910.0 nM 6.04
CHEMBL4434669 — IC50 = 910.0 nM 6.04
CHEMBL4459355 — IC50 = 930.0 nM 6.03
CHEMBL4443558 — IC50 = 1000.0 nM 6.00
CHEMBL4571822 — IC50 = 1000.0 nM 6.00
CHEMBL4541757 — IC50 = 1100.0 nM 5.96
CHEMBL4564517 — IC50 = 1100.0 nM 5.96
CHEMBL4474398 — IC50 = 1100.0 nM 5.96
CHEMBL4459983 — IC50 = 1100.0 nM 5.96
CHEMBL4564599 — IC50 = 1100.0 nM 5.96
CHEMBL4469765 — IC50 = 1200.0 nM 5.92
CHEMBL4459858 — IC50 = 1300.0 nM 5.89
CHEMBL4521518 — IC50 = 1400.0 nM 5.85
CHEMBL4470366 — IC50 = 1400.0 nM 5.85
CHEMBL4551082 — IC50 = 1400.0 nM 5.85
CHEMBL4456390 — IC50 = 1400.0 nM 5.85
CHEMBL4472713 — IC50 = 1500.0 nM 5.82
CHEMBL4467346 — IC50 = 1500.0 nM 5.82
CHEMBL4514950 — IC50 = 1600.0 nM 5.80
CHEMBL4440126 — IC50 = 1600.0 nM 5.80
CHEMBL4456651 — IC50 = 1600.0 nM 5.80
CHEMBL4522151 — IC50 = 1600.0 nM 5.80
CHEMBL4483383 — IC50 = 1700.0 nM 5.77
CHEMBL4448066 — IC50 = 1700.0 nM 5.77
CHEMBL4456379 — IC50 = 1800.0 nM 5.75
CHEMBL4569704 — IC50 = 1800.0 nM 5.75
CHEMBL4471423 — IC50 = 1800.0 nM 5.75