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Assay Detail

CHEMBL4421180

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LOXL2 (unknown origin) using H2O2 substrate incubated for 20 mins by luminescence based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lysyl oxidase homolog 2 (CHEMBL3714029)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.48 6.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4551082 1 6.11
CHEMBL4458145 1 5.82
CHEMBL4442739 1 5.82
CHEMBL4526964 1 5.75
CHEMBL4564517 1 5.70
CHEMBL4521045 1 5.66
CHEMBL4450766 1 5.66
CHEMBL4471295 1 5.66
CHEMBL4434955 1 5.64
CHEMBL4535726 1 5.58
CHEMBL4555200 1 5.52
CHEMBL4441173 1 5.42
CHEMBL4587595 1 5.40
CHEMBL4443558 1 5.40
CHEMBL4456390 1 5.30
CHEMBL4540543 1 5.29
CHEMBL4591569 1 5.02
CHEMBL4436758 1 4.89
CHEMBL4435551 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4551082 IC50 = 770.0 nM 6.11
CHEMBL4458145 IC50 = 1500.0 nM 5.82
CHEMBL4442739 IC50 = 1500.0 nM 5.82
CHEMBL4526964 IC50 = 1800.0 nM 5.75
CHEMBL4564517 IC50 = 2000.0 nM 5.70
CHEMBL4521045 IC50 = 2200.0 nM 5.66
CHEMBL4450766 IC50 = 2200.0 nM 5.66
CHEMBL4471295 IC50 = 2200.0 nM 5.66
CHEMBL4434955 IC50 = 2300.0 nM 5.64
CHEMBL4535726 IC50 = 2600.0 nM 5.58
CHEMBL4555200 IC50 = 3000.0 nM 5.52
CHEMBL4441173 IC50 = 3800.0 nM 5.42
CHEMBL4587595 IC50 = 4000.0 nM 5.40
CHEMBL4443558 IC50 = 4000.0 nM 5.40
CHEMBL4456390 IC50 = 5000.0 nM 5.30
CHEMBL4540543 IC50 = 5100.0 nM 5.29
CHEMBL4591569 IC50 = 9500.0 nM 5.02
CHEMBL4436758 IC50 = 13000.0 nM 4.89
CHEMBL4435551 IC50 = 27000.0 nM 4.57