Assay Detail
Binding
CHEMBL4421181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LOXL2 (unknown origin) using H2O2 substrate incubated for 1 hr by luminescence based assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.53 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518059 | — | — | 1 | 7.19 |
| CHEMBL4439162 | — | — | 1 | 7.18 |
| CHEMBL4435416 | — | — | 1 | 7.14 |
| CHEMBL4570730 | — | — | 1 | 7.13 |
| CHEMBL4590757 | — | — | 1 | 7.11 |
| CHEMBL4472652 | — | — | 1 | 7.10 |
| CHEMBL4468572 | — | — | 1 | 7.09 |
| CHEMBL4534403 | — | — | 1 | 7.07 |
| CHEMBL4552362 | — | — | 1 | 7.05 |
| CHEMBL4483542 | — | — | 1 | 7.03 |
| CHEMBL4516505 | — | — | 1 | 7.02 |
| CHEMBL4529150 | — | — | 1 | 6.92 |
| CHEMBL4535310 | — | — | 1 | 6.85 |
| CHEMBL4547000 | — | — | 1 | 6.85 |
| CHEMBL4517798 | — | — | 1 | 6.82 |
| CHEMBL4461466 | — | — | 1 | 6.82 |
| CHEMBL4593658 | — | — | 1 | 6.77 |
| CHEMBL4573809 | — | — | 1 | 6.77 |
| CHEMBL4471888 | — | — | 1 | 6.75 |
| CHEMBL4451663 | — | — | 1 | 6.75 |
| CHEMBL4466536 | — | — | 1 | 6.70 |
| CHEMBL4454209 | — | — | 1 | 6.66 |
| CHEMBL4548488 | — | — | 1 | 6.62 |
| CHEMBL4437983 | — | — | 1 | 6.62 |
| CHEMBL4576894 | — | — | 1 | 6.58 |
| CHEMBL4548731 | — | — | 1 | 6.58 |
| CHEMBL4549214 | — | — | 1 | 6.55 |
| CHEMBL4533353 | — | — | 1 | 6.55 |
| CHEMBL4441735 | — | — | 1 | 6.54 |
| CHEMBL4584859 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518059 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4439162 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4435416 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4570730 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4590757 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4472652 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4468572 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4534403 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4552362 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4483542 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4516505 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4529150 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4535310 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4547000 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4461466 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4517798 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4593658 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4573809 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4471888 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4451663 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4466536 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4454209 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4437983 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4548488 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4576894 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4548731 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4549214 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4533353 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4441735 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4584859 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4483628 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4476340 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4471297 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4450132 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4584147 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4468175 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4466774 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4515087 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4520094 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4456842 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4549625 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4457392 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4451579 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4442494 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4454433 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4460734 | — | IC50 | = | 19000.0 | nM | 4.72 |