Assay Detail
Binding
CHEMBL4422732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-fused HDAC1 expressed in HEK293 cells Fluor-de-lys as substrate measured after 60 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.43 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL4562156 | — | — | 1 | 7.55 |
| CHEMBL4438671 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4562156 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4438671 | — | IC50 | = | 187.0 | nM | 6.73 |