Assay Detail
Binding
CHEMBL4422795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin)
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.67 | 9.82 |
| Ki | 1 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438063 | — | — | 1 | 9.82 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.70 |
| CHEMBL4438404 | — | — | 1 | 8.31 |
| CHEMBL4543038 | — | — | 1 | 8.09 |
| CHEMBL4452333 | — | — | 1 | 7.94 |
| CHEMBL2401844 | — | — | 1 | 7.82 |
| CHEMBL4593341 | — | — | 1 | 7.72 |
| CHEMBL2401847 | — | — | 1 | 7.55 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 7.44 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.38 |
| CHEMBL4551751 | — | — | 1 | 7.33 |
| CHEMBL2401846 | — | — | 1 | 7.12 |
| CHEMBL2401849 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438063 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL4438404 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4543038 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4452333 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL2401844 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4593341 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2401847 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4551751 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2401846 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2401849 | — | IC50 | = | 2700.0 | nM | 5.57 |