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Assay Detail

CHEMBL4422818

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.
Sangwan R, Rajan R, Mandal PK.
Eur J Med Chem (2018) 158 : 620 -706
PubMed 30245394 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 8.26 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4467135 1 9.00
CHEMBL370056 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4467135 IC50 = 1.0 nM 9.00
CHEMBL370056 IC50 = 30.0 nM 7.52