Assay Detail
Binding
CHEMBL4423048
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Inhibition of human A2B adenosine receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel non-xanthine antagonist of the A<sub>2B</sub> adenosine receptor: From HTS hit to lead structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.11 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273807 | — | — | 1 | 8.70 |
| CHEMBL1672627 | LAS101057 | 1.0 | 1 | 7.62 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273807 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1672627 | LAS101057 | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL113 | CAFFEINE | Ki | = | 10000.0 | nM | 5.00 |