Assay Detail

CHEMBL4423091

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Functional

Antiproliferative activity against human U251 cells after 24 hrs by SRB assay

ChEMBL ↗

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Target

U-251 (CHEMBL615022) ↗

Open DB target context

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U-251 (CHEMBL615022) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target U-251

CHEMBL615022

Anchored from Assay target.

Protein identity U-251

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-251
Confidence	1 — Organism
Curated By	Autocuration

Target

U-251 (CHEMBL615022) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Recent advances in the discovery of small molecules targeting glioblastoma.

Fernandes GFDS, Fernandes BC, Valente V, Dos Santos JL.
Eur J Med Chem (2019) 164 : 8 -26
PubMed 30583248 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.13	6.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4439518	—	—	1	6.16
CHEMBL4447524	—	—	1	6.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4439518	—	IC50	=	700.0	nM	6.16
CHEMBL4447524	—	IC50	=	800.0	nM	6.10