Assay Detail
Binding
CHEMBL4423152
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Inhibition of human COX2 using arachidonic acid as substrate by colorimetric assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.72 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515876 | — | — | 1 | 7.16 |
| CHEMBL4475349 | — | — | 1 | 6.75 |
| CHEMBL4571499 | — | — | 1 | 6.72 |
| CHEMBL4441970 | — | — | 1 | 6.52 |
| CHEMBL4462870 | — | — | 1 | 6.46 |
| CHEMBL4513580 | — | — | 1 | - |
| CHEMBL4470970 | — | — | 1 | - |
| CHEMBL4557726 | — | — | 1 | - |
| CHEMBL4544804 | — | — | 1 | - |
| CHEMBL4570802 | — | — | 1 | - |
| CHEMBL4465969 | — | — | 1 | - |
| CHEMBL4567742 | — | — | 1 | - |
| CHEMBL4590829 | — | — | 1 | - |
| CHEMBL4436511 | — | — | 1 | - |
| CHEMBL4445036 | — | — | 1 | - |
| CHEMBL4449420 | — | — | 1 | - |
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | - |
| CHEMBL4470659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515876 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4475349 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4571499 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4441970 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4462870 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4513580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4470970 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4557726 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4544804 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4570802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4465969 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4567742 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4590829 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4436511 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4445036 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4449420 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL259972 | MOFEZOLAC | IC50 | > | 50000.0 | nM | - |
| CHEMBL4470659 | — | IC50 | > | 50000.0 | nM | - |