Assay Detail
Binding
CHEMBL4423302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid receptor in presence of aldosterone by receptor translocation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.13 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095097 | EPLERENONE | 4.0 | 1 | 7.20 |
| CHEMBL4557032 | — | — | 1 | 7.20 |
| CHEMBL4462110 | — | — | 1 | 7.00 |
| CHEMBL3916929 | BALCINRENONE | 3.0 | 1 | - |
| CHEMBL4540313 | — | — | 1 | - |
| CHEMBL4455600 | — | — | 1 | - |
| CHEMBL4532472 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095097 | EPLERENONE | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4557032 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL4462110 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3916929 | BALCINRENONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4540313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4455600 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4532472 | — | IC50 | > | 10000.0 | nM | - |