Assay Detail
Binding
CHEMBL4423398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERK2 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.08 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434915 | — | — | 1 | 9.15 |
| CHEMBL4571588 | — | — | 1 | 9.15 |
| CHEMBL4449385 | — | — | 1 | 9.10 |
| CHEMBL4435679 | — | — | 1 | 8.96 |
| CHEMBL4532652 | — | — | 1 | 8.92 |
| CHEMBL4588783 | — | — | 1 | 8.80 |
| CHEMBL4567212 | — | — | 1 | 8.72 |
| CHEMBL4458400 | — | — | 1 | 8.57 |
| CHEMBL4535176 | — | — | 1 | 8.54 |
| CHEMBL4442577 | — | — | 1 | 8.51 |
| CHEMBL4533640 | — | — | 1 | 8.46 |
| CHEMBL4476178 | — | — | 1 | 8.44 |
| CHEMBL4524371 | — | — | 1 | 8.27 |
| CHEMBL4547563 | — | — | 1 | 8.25 |
| CHEMBL4470800 | — | — | 1 | 8.14 |
| CHEMBL4463859 | — | — | 1 | 7.95 |
| CHEMBL4569409 | — | — | 1 | 7.75 |
| CHEMBL4518783 | — | — | 1 | 7.75 |
| CHEMBL4472237 | — | — | 1 | 7.70 |
| CHEMBL4473588 | — | — | 1 | 7.65 |
| CHEMBL4462277 | — | — | 1 | 7.59 |
| CHEMBL4435286 | — | — | 1 | 7.52 |
| CHEMBL4554747 | — | — | 1 | 7.45 |
| CHEMBL4439967 | — | — | 1 | 7.44 |
| CHEMBL4457070 | — | — | 1 | 7.42 |
| CHEMBL4471771 | — | — | 1 | 7.03 |
| CHEMBL4470651 | — | — | 1 | 6.70 |
| CHEMBL4517851 | — | — | 1 | 6.20 |
| CHEMBL4529178 | — | — | 1 | - |
| CHEMBL4466965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434915 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4571588 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4449385 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4435679 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4532652 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4588783 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4567212 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4458400 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4535176 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4442577 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4533640 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4476178 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4524371 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4547563 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4470800 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4463859 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL4518783 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL4569409 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL4472237 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL4473588 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL4462277 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL4435286 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL4554747 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4439967 | — | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL4457070 | — | IC50 | = | 38.4 | nM | 7.42 |
| CHEMBL4471771 | — | IC50 | = | 93.3 | nM | 7.03 |
| CHEMBL4470651 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL4517851 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL4529178 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4466965 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4457113 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4585624 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4528740 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4446483 | — | IC50 | > | 1000.0 | nM | - |