Assay Detail
Functional
CHEMBL4423403
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Antiproliferative activity against human COLO205 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.64 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588783 | — | — | 1 | 6.77 |
| CHEMBL4434915 | — | — | 1 | 6.71 |
| CHEMBL4476178 | — | — | 1 | 6.69 |
| CHEMBL4532652 | — | — | 1 | 6.64 |
| CHEMBL4567212 | — | — | 1 | 6.60 |
| CHEMBL4571588 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588783 | — | IC50 | = | 170.49 | nM | 6.77 |
| CHEMBL4434915 | — | IC50 | = | 193.53 | nM | 6.71 |
| CHEMBL4476178 | — | IC50 | = | 203.75 | nM | 6.69 |
| CHEMBL4532652 | — | IC50 | = | 226.91 | nM | 6.64 |
| CHEMBL4567212 | — | IC50 | = | 251.94 | nM | 6.60 |
| CHEMBL4571588 | — | IC50 | = | 388.81 | nM | 6.41 |