Assay Detail
Functional
CHEMBL4423420
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Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.74 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 9.82 |
| CHEMBL4588783 | — | — | 1 | 8.81 |
| CHEMBL4476178 | — | — | 1 | 8.56 |
| CHEMBL4533640 | — | — | 1 | 8.54 |
| CHEMBL4567212 | — | — | 1 | 8.53 |
| CHEMBL4434915 | — | — | 1 | 8.50 |
| CHEMBL4532652 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4588783 | — | IC50 | = | 1.55 | nM | 8.81 |
| CHEMBL4476178 | — | IC50 | = | 2.74 | nM | 8.56 |
| CHEMBL4533640 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL4567212 | — | IC50 | = | 2.93 | nM | 8.53 |
| CHEMBL4434915 | — | IC50 | = | 3.19 | nM | 8.50 |
| CHEMBL4532652 | — | IC50 | = | 3.82 | nM | 8.42 |