Assay Detail
Functional
CHEMBL4423476
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Antiproliferative activity against mouse B-ALL cells expressing wild type BCR-ABL assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B-ALL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.52 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303625 | — | — | 1 | 7.14 |
| CHEMBL4442658 | — | — | 1 | 6.20 |
| CHEMBL4525540 | — | — | 1 | 5.91 |
| CHEMBL4459433 | — | — | 1 | 5.69 |
| CHEMBL4449820 | — | — | 1 | 5.50 |
| CHEMBL4439397 | — | — | 1 | 5.40 |
| CHEMBL4448276 | — | — | 1 | 5.33 |
| CHEMBL4463235 | — | — | 1 | 5.31 |
| CHEMBL4529707 | — | — | 1 | 5.10 |
| CHEMBL4567481 | — | — | 1 | 5.09 |
| CHEMBL4435702 | — | — | 1 | 5.07 |
| CHEMBL4546829 | — | — | 1 | 5.05 |
| CHEMBL4441550 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303625 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4442658 | — | EC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4525540 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4459433 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4449820 | — | EC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL4439397 | — | EC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL4448276 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL4463235 | — | EC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL4529707 | — | EC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL4567481 | — | EC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL4435702 | — | EC50 | = | 8530.0 | nM | 5.07 |
| CHEMBL4546829 | — | EC50 | = | 8880.0 | nM | 5.05 |
| CHEMBL4441550 | — | EC50 | = | 9490.0 | nM | 5.02 |