Assay Detail
Functional
CHEMBL4423481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SUP-B15 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUP-B15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.67 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442658 | — | — | 1 | 6.57 |
| CHEMBL4303625 | — | — | 1 | 5.96 |
| CHEMBL4448276 | — | — | 1 | 5.88 |
| CHEMBL4529707 | — | — | 1 | 5.74 |
| CHEMBL4567481 | — | — | 1 | 5.28 |
| CHEMBL4525540 | — | — | 1 | 4.59 |
| CHEMBL4459433 | — | — | 1 | - |
| CHEMBL4449820 | — | — | 1 | - |
| CHEMBL4439397 | — | — | 1 | - |
| CHEMBL4463235 | — | — | 1 | - |
| CHEMBL4435702 | — | — | 1 | - |
| CHEMBL4546829 | — | — | 1 | - |
| CHEMBL4441550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442658 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4303625 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4448276 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4529707 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4567481 | — | EC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4525540 | — | EC50 | = | 25860.0 | nM | 4.59 |
| CHEMBL4459433 | — | EC50 | > | 49150.0 | nM | - |
| CHEMBL4449820 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4439397 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4463235 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4435702 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4546829 | — | EC50 | > | 43290.0 | nM | - |
| CHEMBL4441550 | — | EC50 | > | 43290.0 | nM | - |