Assay Detail
Functional
CHEMBL4423482
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Antiproliferative activity against human MV411 assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.82 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448276 | — | — | 1 | 6.22 |
| CHEMBL4567481 | — | — | 1 | 6.19 |
| CHEMBL4442658 | — | — | 1 | 6.14 |
| CHEMBL4459433 | — | — | 1 | 6.07 |
| CHEMBL4303625 | — | — | 1 | 5.42 |
| CHEMBL4529707 | — | — | 1 | 4.86 |
| CHEMBL4525540 | — | — | 1 | - |
| CHEMBL4449820 | — | — | 1 | - |
| CHEMBL4439397 | — | — | 1 | - |
| CHEMBL4463235 | — | — | 1 | - |
| CHEMBL4435702 | — | — | 1 | - |
| CHEMBL4546829 | — | — | 1 | - |
| CHEMBL4441550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448276 | — | EC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4567481 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4442658 | — | EC50 | = | 716.0 | nM | 6.14 |
| CHEMBL4459433 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4303625 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4529707 | — | EC50 | = | 13680.0 | nM | 4.86 |
| CHEMBL4525540 | — | EC50 | - | — | - | |
| CHEMBL4449820 | — | EC50 | - | — | - | |
| CHEMBL4439397 | — | EC50 | - | — | - | |
| CHEMBL4463235 | — | EC50 | - | — | - | |
| CHEMBL4435702 | — | EC50 | - | — | - | |
| CHEMBL4546829 | — | EC50 | - | — | - | |
| CHEMBL4441550 | — | EC50 | > | 10000.0 | nM | - |