Assay Detail
Binding
CHEMBL4423745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced current response at holding potential -60 mV by two-electrode voltage clamp method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2a (CHEMBL2096680) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.66 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4530995 | — | — | 1 | 5.12 |
| CHEMBL4467653 | — | — | 1 | 4.57 |
| CHEMBL4452216 | — | — | 1 | 4.55 |
| CHEMBL4531020 | — | — | 1 | 4.41 |
| CHEMBL4572997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4530995 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4467653 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4452216 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4531020 | — | EC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL4572997 | — | EC50 | = | 114400.0 | nM | - |