Assay Detail
Binding
CHEMBL4423747
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced current response at holding potential -60 mV by two-electrode voltage clamp method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2c (CHEMBL2096911) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.53 | 4.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4530995 | — | — | 1 | 4.65 |
| CHEMBL4572997 | — | — | 1 | 4.58 |
| CHEMBL4531020 | — | — | 1 | 4.44 |
| CHEMBL4452216 | — | — | 1 | 4.43 |
| CHEMBL4467653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4530995 | — | EC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4572997 | — | EC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL4531020 | — | EC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL4452216 | — | EC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL4467653 | — | EC50 | = | 113000.0 | nM | - |