Assay Detail

CHEMBL4423797

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ADMET

Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.

Hopper AT, Brockman A, Wise A, Gould J, Barks J, Radke JB, Sibley LD, Zou Y, Thomas S.
J Med Chem (2019) 62 : 1562 -1576
PubMed 30624926 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.04	5.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4468777	FANOTAPRIM	1.0	1	5.14
CHEMBL36	PYRIMETHAMINE	4.0	1	4.93

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4468777	FANOTAPRIM	EC50	=	7300.0	nM	5.14
CHEMBL36	PYRIMETHAMINE	EC50	=	11700.0	nM	4.93