Assay Detail

CHEMBL4423878

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Functional

Antiproliferative activity against human MM1S cells after 72 hrs by MTS assay

ChEMBL ↗

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Target

MM1.S (CHEMBL4296471) ↗

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MM1.S (CHEMBL4296471) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MM1.S

CHEMBL4296471

Anchored from Assay target.

Protein identity MM1.S

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MM1.S
Confidence	1 — Organism
Curated By	Autocuration

Target

MM1.S (CHEMBL4296471) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Dong XW, Zhang JK, Xu L, Che JX, Cheng G, Hu XB, Sheng L, Gao AH, Li J, Liu T, Hu YZ, Zhou YB.
Eur J Med Chem (2019) 164 : 602 -614
PubMed 30639896 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.69	8.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4460323	—	—	1	8.74
CHEMBL451887	CARFILZOMIB	4.0	1	8.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4460323	—	IC50	=	1.8	nM	8.74
CHEMBL451887	CARFILZOMIB	IC50	=	2.3	nM	8.64