Assay Detail
Functional
CHEMBL4424031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H727 cells after 48 hrs by Hoechst 33342 staining-based assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H727 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.70 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL4455065 | — | — | 1 | 7.05 |
| CHEMBL4567455 | — | — | 1 | 5.82 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.70 |
| CHEMBL4474337 | — | — | 1 | 4.60 |
| CHEMBL4572302 | — | — | 1 | 4.52 |
| CHEMBL4532861 | — | — | 1 | - |
| CHEMBL4527723 | — | — | 1 | - |
| CHEMBL4454606 | — | — | 1 | - |
| CHEMBL4547959 | — | — | 1 | - |
| CHEMBL4560978 | — | — | 1 | - |
| CHEMBL4469175 | — | — | 1 | - |
| CHEMBL4452229 | — | — | 1 | - |
| CHEMBL4454439 | — | — | 1 | - |
| CHEMBL4442270 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL573339 | PI-103 | — | 1 | - |
| CHEMBL4547111 | — | — | 1 | - |
| CHEMBL4448514 | — | — | 1 | - |
| CHEMBL4461159 | — | — | 1 | - |
| CHEMBL4450720 | — | — | 1 | - |
| CHEMBL4592479 | — | — | 1 | - |
| CHEMBL4461861 | — | — | 1 | - |
| CHEMBL4454618 | — | — | 1 | - |
| CHEMBL4469180 | — | — | 1 | - |
| CHEMBL4471921 | — | — | 1 | - |
| CHEMBL4467690 | — | — | 1 | - |
| CHEMBL4467615 | — | — | 1 | - |
| CHEMBL4437660 | — | — | 1 | - |
| CHEMBL4435373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4455065 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4567455 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4474337 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4572302 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4442270 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4458835 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - | |
| CHEMBL573339 | PI-103 | IC50 | > | 25000.0 | nM | - |
| CHEMBL4547111 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4527723 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4587270 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4588359 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4462414 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4434921 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4439712 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4442788 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3422587 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4531119 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4440706 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4471061 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL611321 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4454165 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4470571 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4450720 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4435373 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4437660 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4467615 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4467690 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4471921 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4469180 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4454618 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4461861 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4592479 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4454439 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4461159 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4448514 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4532861 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4454606 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4547959 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4560978 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4469175 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4452229 | — | IC50 | > | 25000.0 | nM | - |