Assay Detail
Binding
CHEMBL4424161
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Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophotometric analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.33 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | 7.48 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 7.00 |
| CHEMBL53569 | ANGELICIN | — | 1 | 5.56 |
| CHEMBL499847 | BAKUCHICIN | — | 1 | 5.26 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | - |
| CHEMBL350475 | OSTHENOL | — | 1 | - |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL673 | PARGYLINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL499847 | BAKUCHICIN | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL8706 | CLORGILINE | IC50 | > | 2000.0 | nM | - |
| CHEMBL18116 | TOLOXATONE | IC50 | - | — | - | |
| CHEMBL350475 | OSTHENOL | IC50 | > | 60000.0 | nM | - |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | > | 60000.0 | nM | - |
| CHEMBL71851 | SCOPOLETIN | IC50 | > | 60000.0 | nM | - |
| CHEMBL164660 | PSORALEN | IC50 | > | 60000.0 | nM | - |