Assay Detail
Binding
CHEMBL4424162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.84 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.64 |
| CHEMBL350475 | OSTHENOL | — | 1 | 4.60 |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | 4.59 |
| CHEMBL53569 | ANGELICIN | — | 1 | 4.59 |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | 4.53 |
| CHEMBL71851 | SCOPOLETIN | — | 1 | 4.45 |
| CHEMBL499847 | BAKUCHICIN | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL350475 | OSTHENOL | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL448060 | ISOIMPERATORIN | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL164660 | PSORALEN | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL71851 | SCOPOLETIN | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL499847 | BAKUCHICIN | IC50 | = | 35700.0 | nM | 4.45 |