Assay Detail
Binding
CHEMBL4424163
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Competitive inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by Lineweaver-Burk plot analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.46 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350475 | OSTHENOL | — | 1 | 6.58 |
| CHEMBL53569 | ANGELICIN | — | 1 | 6.34 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | - |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | - |
| CHEMBL448060 | ISOIMPERATORIN | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | - |
| CHEMBL499847 | BAKUCHICIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350475 | OSTHENOL | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL53569 | ANGELICIN | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL673 | PARGYLINE | Ki | - | — | - | |
| CHEMBL8706 | CLORGILINE | Ki | - | — | - | |
| CHEMBL279390 | LAZABEMIDE | Ki | - | — | - | |
| CHEMBL18116 | TOLOXATONE | Ki | - | — | - | |
| CHEMBL448060 | ISOIMPERATORIN | Ki | - | — | - | |
| CHEMBL71851 | SCOPOLETIN | Ki | - | — | - | |
| CHEMBL164660 | PSORALEN | Ki | - | — | - | |
| CHEMBL499847 | BAKUCHICIN | Ki | - | — | - |