Assay Detail
Binding
CHEMBL4424385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse uPA serine protease domain preincubated for 15 mins followed by chromogenic substrate addition
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL1075311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.73 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464577 | — | — | 1 | 7.82 |
| CHEMBL4550668 | — | — | 1 | 6.61 |
| CHEMBL4522772 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464577 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL4550668 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL4522772 | — | Ki | = | 1769.0 | nM | 5.75 |