Assay Detail
Binding
CHEMBL4424403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the intrinsic peri-cellular uPA in mouse CT26 cells assessed as reduction in cell invasion measured every hour by transwell assay
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CT26 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL1075311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.06 | 5.48 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464577 | — | — | 1 | 5.48 |
| CHEMBL4550668 | — | — | 1 | 5.30 |
| CHEMBL4522772 | — | — | 2 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464577 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4550668 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL4522772 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL4522772 | — | Inhibition | - | % | - |