Assay Detail
Binding
CHEMBL4424489
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Inhibition of NS5A in HCV genotype 1b assessed as decrease in viral replication
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 10.26 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4580295 | — | — | 1 | 10.52 |
| CHEMBL4527728 | — | — | 1 | 10.00 |
| CHEMBL3360472 | — | — | 1 | - |
| CHEMBL3808674 | — | — | 1 | - |
| CHEMBL4438612 | — | — | 1 | - |
| CHEMBL4577499 | — | — | 1 | - |
| CHEMBL4569232 | — | — | 1 | - |
| CHEMBL4461797 | — | — | 1 | - |
| CHEMBL4461377 | — | — | 1 | - |
| CHEMBL4461150 | — | — | 1 | - |
| CHEMBL4452034 | — | — | 1 | - |
| CHEMBL4542548 | — | — | 1 | - |
| CHEMBL4440064 | — | — | 1 | - |
| CHEMBL3039514 | ELBASVIR | 4.0 | 1 | - |
| CHEMBL4450175 | — | — | 1 | - |
| CHEMBL4533911 | — | — | 1 | - |
| CHEMBL4454064 | — | — | 1 | - |
| CHEMBL4582225 | — | — | 1 | - |
| CHEMBL4577346 | — | — | 1 | - |
| CHEMBL4575633 | — | — | 1 | - |
| CHEMBL4560981 | — | — | 1 | - |
| CHEMBL4524514 | — | — | 1 | - |
| CHEMBL4543823 | — | — | 1 | - |
| CHEMBL4566096 | — | — | 1 | - |
| CHEMBL4552270 | — | — | 1 | - |
| CHEMBL4578481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4580295 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4527728 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3360472 | — | EC50 | = | 0.002 | nM | - |
| CHEMBL3808674 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4438612 | — | EC50 | = | 0.003 | nM | - |
| CHEMBL4577499 | — | EC50 | > | 1.0 | nM | - |
| CHEMBL4569232 | — | EC50 | - | — | - | |
| CHEMBL4461797 | — | EC50 | = | 0.0045 | nM | - |
| CHEMBL4461377 | — | EC50 | - | — | - | |
| CHEMBL4461150 | — | EC50 | - | — | - | |
| CHEMBL4452034 | — | EC50 | - | — | - | |
| CHEMBL4542548 | — | EC50 | = | 0.0016 | nM | - |
| CHEMBL4440064 | — | EC50 | = | 0.0036 | nM | - |
| CHEMBL3039514 | ELBASVIR | EC50 | = | 0.003 | nM | - |
| CHEMBL4450175 | — | EC50 | - | — | - | |
| CHEMBL4533911 | — | EC50 | - | — | - | |
| CHEMBL4454064 | — | EC50 | - | — | - | |
| CHEMBL4582225 | — | EC50 | - | — | - | |
| CHEMBL4577346 | — | EC50 | - | — | - | |
| CHEMBL4575633 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4560981 | — | EC50 | = | 0.006 | nM | - |
| CHEMBL4524514 | — | EC50 | - | — | - | |
| CHEMBL4543823 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4566096 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4552270 | — | EC50 | = | 0.004 | nM | - |
| CHEMBL4578481 | — | EC50 | - | — | - |