Assay Detail
Binding
CHEMBL4424490
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Inhibition of NS5A in HCV genotype 2a assessed as decrease in viral replication
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 2a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 10.00 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360472 | — | — | 1 | 10.00 |
| CHEMBL3039514 | ELBASVIR | 4.0 | 1 | - |
| CHEMBL3808674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360472 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3039514 | ELBASVIR | EC50 | = | 0.003 | nM | - |
| CHEMBL3808674 | — | EC50 | = | 0.005 | nM | - |