Assay Detail
Binding
CHEMBL4424495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NS5A L31V mutant in HCV genotype 1a assessed as decrease in viral replication
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 10.52 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4575633 | — | — | 1 | 10.52 |
| CHEMBL4560981 | — | — | 1 | 10.52 |
| CHEMBL4524514 | — | — | 1 | - |
| CHEMBL4543823 | — | — | 1 | - |
| CHEMBL4566096 | — | — | 1 | - |
| CHEMBL4552270 | — | — | 1 | - |
| CHEMBL4580295 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4575633 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4560981 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL4524514 | — | EC50 | - | — | - | |
| CHEMBL4543823 | — | EC50 | - | — | - | |
| CHEMBL4566096 | — | EC50 | - | — | - | |
| CHEMBL4552270 | — | EC50 | = | 0.005 | nM | - |
| CHEMBL4580295 | — | EC50 | = | 0.007 | nM | - |