Assay Detail
Binding
CHEMBL4424674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carbonic anhydrase 9 (unknown origin) expressed in Escherichia coli BL21 by stopped-flow CO2 hydration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.28 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064554 | — | — | 1 | 8.70 |
| CHEMBL218382 | — | — | 1 | 7.16 |
| CHEMBL3622044 | — | — | 1 | 7.10 |
| CHEMBL425287 | — | — | 1 | 6.60 |
| CHEMBL4550943 | — | — | 1 | 6.58 |
| CHEMBL4468079 | — | — | 1 | 6.35 |
| CHEMBL408967 | — | — | 1 | 6.12 |
| CHEMBL4547186 | — | — | 1 | 6.07 |
| CHEMBL4104342 | — | — | 1 | 5.99 |
| CHEMBL374721 | — | — | 1 | 5.93 |
| CHEMBL4567341 | — | — | 1 | 4.73 |
| CHEMBL4086075 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064554 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL218382 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3622044 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL425287 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4550943 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL4468079 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL408967 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL4547186 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL4104342 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL374721 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL4567341 | — | Ki | = | 18540.0 | nM | 4.73 |
| CHEMBL4086075 | — | Ki | = | 90590.0 | nM | 4.04 |