Assay Detail
Binding
CHEMBL4424675
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Inhibition of carbonic anhydrase 2 (unknown origin) by stopped-flow CO2 hydration assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.36 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218382 | — | — | 1 | 6.57 |
| CHEMBL4064554 | — | — | 1 | 6.47 |
| CHEMBL408967 | — | — | 1 | 5.83 |
| CHEMBL425287 | — | — | 1 | 5.62 |
| CHEMBL4547186 | — | — | 1 | 5.35 |
| CHEMBL4104342 | — | — | 1 | 5.33 |
| CHEMBL4550943 | — | — | 1 | 5.28 |
| CHEMBL3622044 | — | — | 1 | 5.06 |
| CHEMBL374721 | — | — | 1 | 4.99 |
| CHEMBL4567341 | — | — | 1 | 4.28 |
| CHEMBL4468079 | — | — | 1 | 4.16 |
| CHEMBL4086075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218382 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4064554 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL408967 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL425287 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL4547186 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL4104342 | — | Ki | = | 4730.0 | nM | 5.33 |
| CHEMBL4550943 | — | Ki | = | 5310.0 | nM | 5.28 |
| CHEMBL3622044 | — | Ki | = | 8640.0 | nM | 5.06 |
| CHEMBL374721 | — | Ki | = | 10330.0 | nM | 4.99 |
| CHEMBL4567341 | — | Ki | = | 51940.0 | nM | 4.28 |
| CHEMBL4468079 | — | Ki | = | 69640.0 | nM | 4.16 |
| CHEMBL4086075 | — | Ki | = | 678960.0 | nM | - |