Assay Detail
Binding
CHEMBL4424676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carbonic anhydrase 9 (unknown origin) expressed in Escherichia coli BL21 by isothermal calorimetry assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.77 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064554 | — | — | 1 | 7.46 |
| CHEMBL3622044 | — | — | 1 | 6.62 |
| CHEMBL218382 | — | — | 1 | 6.22 |
| CHEMBL221802 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064554 | — | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL3622044 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL218382 | — | Kd | = | 605.0 | nM | 6.22 |
| CHEMBL221802 | — | Kd | - | — | - |