Assay Detail
Functional
CHEMBL4424726
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Antiproliferative activity against human MCF7 cells after 3 days by CellTiter-Glo luminescent cell viability assay
13
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.02 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449709 | — | — | 1 | 9.70 |
| CHEMBL4447340 | — | — | 1 | 9.70 |
| CHEMBL4439408 | — | — | 2 | 9.52 |
| CHEMBL4539802 | — | — | 1 | 9.52 |
| CHEMBL4437985 | — | — | 1 | 9.40 |
| CHEMBL4464224 | — | — | 1 | 9.15 |
| CHEMBL4443826 | — | — | 2 | 9.10 |
| CHEMBL4464058 | — | — | 1 | 9.05 |
| CHEMBL1087419 | — | — | 1 | 8.92 |
| CHEMBL4464146 | — | — | 2 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449709 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4447340 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4439408 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4539802 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4437985 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4439408 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4464224 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4443826 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4464058 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1087419 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4464146 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4443826 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4464146 | — | IC50 | = | 20.0 | nM | 7.70 |