Assay Detail
Binding
CHEMBL4424976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAGL in African green monkey COS cell homogenates using [3H]-arachidonoylglycerol as substrate measured after 20 mins by scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Plant-Based Modulators of Endocannabinoid Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.22 | 4.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | — | 1 | 4.34 |
| CHEMBL422704 | CANNABICHROMENE | — | 1 | 4.30 |
| CHEMBL497318 | CANNABIGEROL | 2.0 | 1 | 4.02 |
| CHEMBL74415 | CANNABINOL | 3.0 | 1 | - |
| CHEMBL463843 | CANNABIGEROLIC ACID | — | 1 | - |
| CHEMBL2387742 | CANNABIDIVARIN | 2.0 | 1 | - |
| CHEMBL498672 | CANNABIDIOLIC ACID | 2.0 | 1 | - |
| CHEMBL190461 | CANNABIDIOL | 4.0 | 1 | - |
| CHEMBL4564251 | — | — | 1 | - |
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL422704 | CANNABICHROMENE | IC50 | = | 50100.0 | nM | 4.30 |
| CHEMBL497318 | CANNABIGEROL | IC50 | = | 95700.0 | nM | 4.02 |
| CHEMBL74415 | CANNABINOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL463843 | CANNABIGEROLIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL2387742 | CANNABIDIVARIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL498672 | CANNABIDIOLIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL190461 | CANNABIDIOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL4564251 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | IC50 | > | 50000.0 | nM | - |