Assay Detail
Functional
CHEMBL4425072
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Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 24 hrs before [3H]-hypoxanthine addition and measured after 24 hrs by microplate scintillation counting based microculture radioisotope technique
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trichothecenes from a Soil-Derived Trichoderma brevicompactum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.00 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568390 | — | — | 1 | 8.66 |
| CHEMBL4463552 | — | — | 1 | 7.00 |
| CHEMBL2047177 | TRICHODERMOL | — | 1 | 5.15 |
| CHEMBL4518924 | — | — | 1 | 5.13 |
| CHEMBL4534533 | — | — | 1 | 5.06 |
| CHEMBL4449739 | — | — | 1 | 5.02 |
| CHEMBL4467116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568390 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4463552 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2047177 | TRICHODERMOL | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4518924 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4534533 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4449739 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4467116 | — | IC50 | - | — | - |