Assay Detail
Functional
CHEMBL4425228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NB39 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo luminescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.31 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | 3.0 | 1 | 8.00 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103879 | GANETESPIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 240.0 | nM | 6.62 |