Assay Detail
Binding
CHEMBL4425319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PDE4D7 catalytic domain expressed in baculovirus infected sf9 cells using cAMP as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.70 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127944 | — | — | 1 | 8.30 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 8.24 |
| CHEMBL1232082 | — | — | 1 | 7.72 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.54 |
| CHEMBL1229663 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127944 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1232082 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL1229663 | — | IC50 | < | 1.0 | nM | - |