Assay Detail
Binding
CHEMBL4425321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D2 catalytic domain (79 to 438 residues) Escherichia coli BL21-CodonPlus(DE3) cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.37 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430893 | (-)-ROLIPRAM | — | 1 | 6.64 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.26 |
| CHEMBL1229585 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430893 | (-)-ROLIPRAM | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1229585 | — | IC50 | = | 631.0 | nM | 6.20 |